唐明希，医学博士，博士后。bet体育手机版附属医院病理科教授，硕士研究生导师，无党派人士。四川省海外高层次留学人才，四川省卫健委学术技术带头人。四川省欧美同学会、四川省留学人员联谊会经济与医卫专委会理事、医卫分会副会长、四川省留日分会理事。科技部国际科技合作专项评审专家，教育部、四川省、重庆市、贵州省及河北省科技评审专家。中国病理中青年国际合作成员，泸州市留联会、bet体育手机版海联会理事。主持各级科研及教改课题20余项，发表学术论文70余篇（其中SCI收录28篇，中文核心近40篇）。发表国际英文专著1部，获四川省科技进步三等奖1项、国家发明专利3项。

1. 学习及工作经历

1996.09-1999.06，重庆医科大学临床医学专业

2000.12-2003.03，日本国名古屋市立大学医学部，第一病理教研室硕士研究生（硕博连读）

2003.04-2007.03，日本国名古屋市立大学医学部，第一病理教研室博士（硕博连读）

2007.04-2009.03，日本国名古屋市立大学医学部，第一病理教研室博士后

2008.06-至今， bet体育手机版附属医院病理科

2. 联系方式

邮箱：mxtang69@163.com

3. 研究方向

（1）肿瘤、感染性疾病等的分子病理及诊断等。

（2）神经退行性病变。

4.目前承担项目

（1）年龄依赖性神经退行性病变DNA甲基化图谱构建及生物标志的发现（四川省科技厅科技支撑计划）；

（2）一种新型合成短肽对晚期前列腺癌 、肺癌、甲状腺癌骨转移顽固性疼痛的临床前共性镇痛效果及与吗啡的比较 、对吗啡耐受的影响和机制研究（泸州市社会发展重点研发项目）

（3）新型多肽 P10581 抑制恶性肿瘤骨转移疼痛及降低吗啡耐受的机制研究（bet体育手机版重点项目）等。

5. 代表性论文

[1] Nan Zhou, et al, Mingxi Tang, et al. Two types of peptides derived from the neurotoxin GsMTx4 inhibit a mechanosensitive potassium channel by modifying the mechanogate. J. Biol. Chem. (2022) 298(9) 102326 1-6

[2] Wang XM,Huang XD,Tang MX, et l. Maternal Diabetes Induces Autism-Like Behavior through Hyperglycemia-Mediated Persistent Oxidative Stress and Suppression of Superoxide Dismutase2. Proc Natl Acad Sci USA.2019;116(47):23743-23752

[3] Li H, et al, Tang M, et al, Tang QY. The neuropeptide GsMTx4 inhibits a mechanosensitive BK channel through the voltage-dependent modification specific to mechano-gating. J Biol Chem. 2019;294,11892-11909

[4] Xiaoqin Tang, et al, Mingxi Tang. DNA methylation profiles in the hippocampus of an Alzheimer’s disease mouse model at mid-stage neurodegeneration. Int J Clin Exp Med. 2018;11(11);11876-88

[5] Yuan Zhang, et al, Mingxi Tang. Human Papillomavirus (HPV) Genotype Distribution in Women with Cervical Lesions in Southern Sichuan of China.Int J Clin Exp Med. 2018;11(6)6152-61

[6] Sibei Ruan, et al, Mingxi Tang. HER-2 status and its clinicopathologic significance in breast cancer in patients from southwest China: re-evaluation of correlation between results from FISH and IHC. Int J Clin Exp Pathol. 2017;10(7):7270-76

[7] Naiki-Ito A, Chemonarin T, Mingxi Tang, et al. Ellagic acid, a component of pomegranate fruit juice, suppresses androgen-dependent prostate carcinogenesis via induction of apoptosis. Prostate.2015;75(2):151-60

[8] Yong Liu, et al, Mingxi Tang. HLJ1 is a novel biomarker for colorectal carcinoma progression and overall patient survival. Int J Clin Exp Pathol. 2014;7(3):969-77

[9] Joseph A, Mingxi Tang, et al, Tang YP. Temporal association of elevated cholecystokininergic tone and adolescent trauma is critical for posttraumatic stress disorder-like behavior in adult mice. Proc Natl Acad Sci USA.2013;110(16):6589-94

[10] Mingxi Tang, Anu Joseph, Qian Chen, Jianwei Jiao and Ya-Ping Tang CCKergic System, Hypothalamus-Pituitary-Adrenal (HPA) Axis, and Early-Life Stress (ELS). GLUCOCORTICOIDS 2012; 1(2):33-52

[11] Satoru Takahashi1, Mingxi Tang, et al, Tomoyuki Shirai. Therapeutic Targeting of Angiotensin II Receptor Type 1 to Regulate Androgen Receptor in Prostate Cancer. Prostate. 2012;72(14):1559-72

[12] Ogawa K, Tang M, et al, Shirai T. Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells. Cancer Sci.2012;103(5):860-7

[13] Mingxi Tang, et al,Tomoyuki Shirai. Effects of Nobiletin on PhIP Induced Prostate and Colon Carcinogenesis in F344 Rats. Nutr Cancer.2011;63(2):227-233.

[14] Kentaro T, Satoru T, Mingxi Tang,et al. Hypertension is positively associated with prostate cancer development in the TRAP transgenic rat model. Pathol Int.2011;61(4):202-9.

[15] Qian Chen, Mingxi Tang, et al, Ya-Ping Tang. Bi-Directional Effect of Cholecystokinin Receptor-2 Overexpression on Stress-Triggered Fear Memory and Anxiety in the Mouse. PLoS One.2010,5(12): e15999

[16] Mingxi Tang, et al,Tomoyuki Shirai. Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk Inhibitor. Pathol Int.2009;59(11):790-96.

[17] Mingxi Tang, et al, Tomoyuki Shirai. Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells. Cancer Sci. 2007;98(4):471-7.